Multiple behavioral anomalies in GluR2 mutant mice exhibiting enhanced LTP.

doi:10.1016/s0166-4328(98)00002-3

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Article

Multiple behavioral anomalies in GluR2 mutant mice exhibiting enhanced LTP.

Behavioural brain research - 1 Sept 1998

Gerlai R, Henderson J T, Roder J C, Jia Z

Abstract excerpt

We have previously disrupted the ionotropic glutamate receptor type 2 gene (GluR2) using gene targeting in embryonic stem cells and generated mice which lacked the GluR2 gene product. Neurophysiological analyses of these mice showed a markedly enhanced long-term potentiation (LTP) and a 9-fold in...

Topics

Animals
Behavior, Animal
Brain
Hippocampus
Long-Term Potentiation
Male
Maze Learning
Mice
Mice, Neurologic Mutants
Mutation
Orientation
Postural Balance
Receptors, AMPA

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