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Article

Deletion of the Coffin-Lowry syndrome gene Rsk2 in mice is associated with impaired spatial learning and reduced control of exploratory behavior.

Behavior genetics - 1 Jan 2007

Poirier R, Jacquot S, Vaillend C, Soutthiphong A A, Libbey M, Davis S, Laroche S, Hanauer A, Welzl H, Lipp H-P, Wolfer D P

Abstract excerpt

Coffin-Lowry Syndrome (CLS) is an X-linked syndromic form of mental retardation associated with skeletal abnormalities. It is caused by mutations of the Rsk2 gene, which encodes a growth factor regulated kinase. Gene deletion studies in mice have shown an essential role for the Rsk2 gene in osteo...

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Source

Identifiers

PMID: 17033934
DOI: 10.1007/s10519-006-9116-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17033934-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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