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Article

ApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 mice.

PloS one - 1 Jan 2013

Antes Ran, Ezra-Elia Raaya, Weinberger Dov, Solomon Arie, Ofri Ron, Michaelson Daniel M

Abstract excerpt

The vertebrate retina, which is part of the central nervous system, is a window into the brain. The present study investigated the extent to which the retina can be used as a model for studying the pathological effects of apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD). Immunohistochemical studies of retinas from young (4 months old) apoE4-targeted replacement mice...

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Identifiers

PMID: 23741431
DOI: 10.1371/journal.pone.0064949
PMCID: PMC3669199

Genes

ERG
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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