Influence of ApoE polymorphism on synaptic morphometry during aging in the dentate gyrus of ApoE knockout and human ApoE transgenic mice

Abstract excerpt

Of the three forms of human Apolipoprotein E (ApoE2, ApoE3 and ApoE4), the ?4 allele coding for ApoE4 is associated with a higher risk of developing Alzheimer's disease (AD) and an earlier age of onset, whereas ?2 may be protective. The mechanisms underlying such influences are still unclear. This thesis has investigated the influence of ApoE polymorphism on structural synaptic parameters in the middle molecular l...

Topics

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• Alzheimer's disease research and treatments
• Apolipoprotein E3
• Dementia and Cognitive Impairment Research
• Glial Fibrillary Acidic Protein
• Maze Learning
• Memory
• Nerve Growth Factor
• Neuronal Plasticity

Identifiers and source

Literature Corpus work

e4c4cb81-04d6-5bdc-bd06-5bd17c39cd03

DOI

10.21954/ou.ro.00004aae