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ApoE4 Delays Dendritic Spine Formation during Neuron Development and Accelerates Loss of Mature Spines <i>in Vitro</i>

13 Dec 2013

Abstract excerpt

The ε4 allele of the gene that encodes apolipoprotein E (APOE4) is the greatest genetic risk factor for Alzheimer's disease (AD), while APOE2 reduces AD risk, compared to APOE3. The mechanism(s) underlying the effects of APOE on AD pathology remains unclear. In vivo, dendritic spine density is lower in APOE4-targeted replacement (APOE-TR) mice compared with APOE2- and APOE3-TR mice. To investigate whether this...

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PMID: 24328732
DOI: 10.1042/an20130043

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