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Article

Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.

Neurobiology of aging - 1 Sept 2014

Klein Rebecca C, Acheson Shawn K, Mace Brian E, Sullivan Patrick M, Moore Scott D

Abstract excerpt

The human APOE4 allele is associated with an early age of onset and increased risk of Alzheimer's disease (AD). Apolipoprotein E is secreted as part of a high-density lipoprotein-like particle by glial cells in the brain for the primary purpose of transport of lipophilic compounds involved in the maintenance of synapses. Previous studies examining synaptic integrity in the amygdala of human apoE targeted...

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Identifiers

PMID: 24698766
DOI: 10.1016/j.neurobiolaging.2014.02.019
PMCID: PMC4248786

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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