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Article

Attenuation of lithium-induced natriuresis and kaliuresis in P2Y₂ receptor knockout mice.

American journal of physiology. Renal physiology - 1 Aug 2013

Zhang Yue, Li Lijun, Kohan Donald E, Ecelbarger Carolyn M, Kishore Bellamkonda K

Abstract excerpt

Whole body knockout (KO) of the P2Y₂ receptor (P2Y₂R) results in enhanced vasopressin V2 receptor activity and increased renal Na⁺ conservation. We hypothesized that P2Y₂R KO mice would be less sensitive to lithium-induced natriuresis and kaliuresis due to attenuated downregulation of one or more of the major renal Na⁺ or K⁺ transporter/channel proteins. KO and wild-type (WT) mice were fed a control or...

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Identifiers

PMID: 23739592
DOI: 10.1152/ajprenal.00464.2012
PMCID: PMC4596727

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