Article
Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations.
Disease models & mechanisms - 1 May 2025
Mungara Priyanka, MacNaughton Kristina, Ullah A K M Shahid, Essuman Grace, Chelangarimiyandoab Forough, Mumtaz Rizwan, Hennings J Christopher, Hübner Christian A, Eladari Dominique, Alexander R Todd, Cordat Emmanuelle
Abstract excerpt
Distal renal tubular acidosis (dRTA) results in metabolic acidosis owing to impaired urinary acidification and can result in an unexplained urinary sodium-wasting phenotype. We report the generation and characterization of a novel dRTA mutant mouse line, Ae1 L919X knock-in (KI). Homozygous L919X KI mice exhibit typical dRTA features, including reduced ability to acidify urine in response to an acid load. This...
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