Article
Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome.
The Journal of biological chemistry - 4 Oct 2002
Lorenz John N, Baird Nancy R, Judd Louise M, Noonan William T, Andringa Anastasia, Doetschman Thomas, Manning Patrice A, Liu Lynne H, Miller Marian L, Shull Gary E
Abstract excerpt
ROMK is an apical K(+) channel expressed in the thick ascending limb of Henle (TALH) and throughout the distal nephron of the kidney. Null mutations in the ROMK gene cause type II Bartter's syndrome, in which abnormalities of electrolyte, acid-base, and fluid-volume homeostasis occur because of defective NaCl reabsorption in the TALH. To understand better the pathogenesis of type II Bartter's syndrome, we...
Topics
- Animals
- Bartter Syndrome
- Base Sequence
- Body Weight
- DNA Primers
- Disease Models, Animal
- Gene Library
- Genotype
- Glomerular Filtration Rate
- Humans