Article

Urinary Sodium Wasting and Disrupted Collecting Duct Function in Mice with dRTA-Causing <i>SLC4A1</i> Mutations

2024-08-21

Abstract excerpt

Distal renal tubular acidosis (dRTA) results in metabolic acidosis due to impaired urinary acidification and can also result in an unexplained urinary sodium-wasting phenotype. Here, we report the generation and characterization of a novel dRTA mutant mouse line, Ae1 L919X knockin (KI). Homozygous L919X KI mice exhibit typical dRTA features including a reduced ability to acidify urine in response to an acid load....

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Literature Corpus work: ba07dff4-e8ff-558f-8e36-fa091dd8360c
DOI: 10.1101/2024.08.21.608692

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