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Article

Lithium in Bipolar Disorder: Renal Mechanisms, Nephrotoxicity Phenotypes, and a Shared-Care Pathway for Clinical Practice.

International journal of molecular sciences - 28 Jul 2026

Rijavec Nikolina, Večerić-Haler Željka

Abstract excerpt

Lithium remains a cornerstone mood stabilizer for bipolar disorder, with strong evidence for relapse prevention and a unique association with reduced suicide risk. Its benefit is counterbalanced by renal adverse effects, ranging from impaired urinary concentrating capacity and nephrogenic diabetes insipidus (NDI) to chronic tubulointerstitial nephropathy with progressive loss of glomerular filtration rate in a...

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Antimanic Agents
Aquaporin 2
Bipolar Disorder
Diabetes Insipidus, Nephrogenic
Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42589388
DOI: 10.3390/ijms27156730
PMCID: PMC13467549

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