Article
Potassium conservation is impaired in mice with reduced renal expression of Kir4.1.
American journal of physiology. Renal physiology - 1 Nov 2018
Malik Sundeep, Lambert Emily, Zhang Junhui, Wang Tong, Clark Heather L, Cypress Michael, Goldman Bruce I, Porter George A, Pena Salvador, Nino Wilson, Gray Daniel A
Abstract excerpt
To better understand the role of the inward-rectifying K channel Kir4.1 (KCNJ10) in the distal nephron, we initially studied a global Kir4.1 knockout mouse (gKO), which demonstrated the hypokalemia and hypomagnesemia seen in SeSAME/EAST syndrome and was associated with reduced Na/Cl cotransporter (NCC) expression. Lethality by ~3 wk, however, limits the usefulness of this model, so we developed a kidney-specific...
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