Article
Strong purifying selection at synonymous sites in D. melanogaster.
PLoS genetics - 1 May 2013
Lawrie David S, Messer Philipp W, Hershberg Ruth, Petrov Dmitri A
Abstract excerpt
Synonymous sites are generally assumed to be subject to weak selective constraint. For this reason, they are often neglected as a possible source of important functional variation. We use site frequency spectra from deep population sequencing data to show that, contrary to this expectation, 22% of four-fold synonymous (4D) sites in Drosophila melanogaster evolve under very strong selective constraint while few,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.