Article

Extreme purifying selection against point mutations in the human genome

2021-08-23

Abstract excerpt

Genome sequencing of tens of thousands of humans has enabled the measurement of large selective effects for mutations to protein-coding genes. Here we describe a new method, called ExtRaINSIGHT, for measuring similar selective effects in noncoding as well as in coding regions of the human genome. ExtRaINSIGHT estimates the prevalance of strong purifying selection, or “ultraselection” ( λ s ), as the fractional d...

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Literature Corpus work: dd3c3dca-8e0e-59bc-9e31-b88f06131057
DOI: 10.1101/2021.08.23.457339

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