Article
Inferring parameters of mutation, selection and demography from patterns of synonymous site evolution in Drosophila.
Genetics - 1 Jan 2001
McVean G A, Vieira J
Abstract excerpt
Selection acting on codon usage can cause patterns of synonymous evolution to deviate considerably from those expected under neutrality. To investigate the quantitative relationship between parameters of mutation, selection, and demography, and patterns of synonymous site divergence, we have developed a novel combination of population genetic models and likelihood methods of phylogenetic sequence analysis....
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