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Article

Strong evidence for lineage and sequence specificity of substitution rates and patterns in Drosophila.

Molecular biology and evolution - 1 Jul 2009

Singh Nadia D, Arndt Peter F, Clark Andrew G, Aquadro Charles F

Abstract excerpt

Rates of single nucleotide substitution in Drosophila are highly variable within the genome, and several examples illustrate that evolutionary rates differ among Drosophila species as well. Here, we use a maximum likelihood method to quantify lineage-specific substitutional patterns and apply this method to 4-fold degenerate synonymous sites and introns from more than 8,000 genes aligned in the Drosophila...

Topics

Animals
Base Composition
Drosophila
Evolution, Molecular
Genome, Insect
Introns
Likelihood Functions
Mutation
Phylogeny
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19351792
DOI: 10.1093/molbev/msp071
PMCID: PMC2734147

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