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Article

Purifying selection maintains highly conserved noncoding sequences in Drosophila.

Molecular biology and evolution - 1 Oct 2007

Casillas Sònia, Barbadilla Antonio, Bergman Casey M

Abstract excerpt

The majority of metazoan genomes consist of nonprotein-coding regions, although the functional significance of most noncoding DNA sequences remains unknown. Highly conserved noncoding sequences (CNSs) have proven to be reliable indicators of functionally constrained sequences such as cis-regulatory elements and noncoding RNA genes. However, CNSs may arise from nonselective evolutionary processes such as genomic...

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PMID: 17646256
DOI: 10.1093/molbev/msm150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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