Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936.

doi:10.1371/journal.pone.0080513

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Article

Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936.

PloS one - 1 Jan 2013

Lyall Donald M, Royle Natalie A, Harris Sarah E, Bastin Mark E, Maniega Susana Muñoz, Murray Catherine, Lutz Michael W, Saunders Ann M, Roses Allen D, del Valdés Hernández Maria C, Starr John M, Porteous David J, Wardlaw Joanna M, Deary Ian J

Abstract excerpt

The APOE ε and TOMM40 rs10524523 ('523') variable length poly-T repeat gene loci have been significantly and independently associated with Alzheimer's disease (AD) related phenotypes such as age of clinical onset. Hippocampal atrophy has been significantly associated with memory impairment, a characteristic of AD. The current study aimed to test for independent effects of APOE ε and TOMM40 '523' genotypes on...

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PMID: 24260406
DOI: 10.1371/journal.pone.0080513
PMCID: PMC3829876

Genes

APOE
TOMM40

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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