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Article

Differences in induction of sister chromatid exchanges in MNNG-resistant HeLa S3 Mer- cell lines.

Carcinogenesis - 1 Jul 1990

Ishida R, Utsumi K R

Abstract excerpt

All N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-resistant (MR) cell lines of HeLa S3 Mer- cells tested were found to be defective in O6-methylguanine-DNA methyltransferase and more sensitive than HeLa Mer+ cells to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-1-nitroso-ure a, like the parental HeLa S3 Mer- cells. MR10-1 and MR1-3 cells were also highly resistant to induction of sister chromatid...

Topics

Cell Survival
Drug Resistance
HeLa Cells
Humans
Methylnitronitrosoguanidine
Mutation
Purines
Sister Chromatid Exchange

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2372878
DOI: 10.1093/carcin/11.7.1209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2372878-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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