The sensitivities of SV40-transformed human fibroblasts to monofunctional and DNA-crosslinking alkylating agents.

doi:10.1016/0921-8777(91)90040-v

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Article

The sensitivities of SV40-transformed human fibroblasts to monofunctional and DNA-crosslinking alkylating agents.

Mutation research - 1 Jan 1991

Miyakoshi J, Scudiero D A, Allalunis-Turner J, Day R S

Abstract excerpt

4 repair-deficient (Mer-) and 2 repair-proficient (Mer+) lines of SV40-transformed human fibroblasts were assayed for colony-forming ability after treatment with MNNG, methyl methanesulfonate (MMS), 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea (HECNU). The sensitivities to MMS, BCNU and HECNU of these SV40-transformed lines were similar to those of...

Topics

Carmustine
Cell Line, Transformed
Cell Survival
DNA Repair
DNA, Viral
Fibroblasts
Glutathione
Humans
Methyl Methanesulfonate
Methylnitronitrosoguanidine
Mutagens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nitrosourea Compounds

Phenotype

RNA, Messenger

RNA, Viral

Simian virus 40

Source

Open in PubMed

Identifiers

PMID: 1846027
DOI: 10.1016/0921-8777(91)90040-v

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1846027-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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