O6-methylguanine (O6-MeG) and cytotoxicity: reversion analysis involving an N-methyl-N'-nitro-N-nitrosoguanidine-sensitive, O6-MeG-DNA methyltransferase-deficient HeLa cell mutant.

doi:10.1093/carcin/11.5.777

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Article

O6-methylguanine (O6-MeG) and cytotoxicity: reversion analysis involving an N-methyl-N'-nitro-N-nitrosoguanidine-sensitive, O6-MeG-DNA methyltransferase-deficient HeLa cell mutant.

Carcinogenesis - 1 May 1990

Kalamegham R, Ebisuzaki K

Abstract excerpt

In a previous communication, we proposed that N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced cytotoxicity in an O6-methylguanine (O6-MeG)-DNA methyltransferase-deficient (MT-) HeLa cell mutant was mainly the consequence of DNA strand breaks resulting from the failure to remove O6-MeG lesions...

Topics

Cell Survival
Clone Cells
DNA Damage
DNA Repair
Guanine
HeLa Cells
Humans
Methylnitronitrosoguanidine
Methyltransferases
Mutation
O(6)-Methylguanine-DNA Methyltransferase
Purines

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