Article
Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.
Biochemical and biophysical research communications - 28 Jun 2013
Poi Ming J, Knobloch Thomas J, Yuan Chunhua, Tsai Ming-Daw, Weghorst Christopher M, Li Junan
Abstract excerpt
The INK4a-ARF locus plays a central role in the development of pancreatic tumors as evidenced by the fact that up to 98% of pancreatic tumor specimens harbored genetic alterations at the INK4a-ARF locus. Interestingly, in addition to the well-known P16(INK4A) (P16) and P14ARF tumor suppressors, the INK4a-ARF locus in pancreas encodes another protein, P12, whose structure, function, and contributions to pancreatic...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Cell Line, Tumor
- Cell Transformation, Neoplastic
- Cohort Studies
- Cyclin-Dependent Kinase Inhibitor p16
- G1 Phase Cell Cycle Checkpoints
- Gene Expression Regulation, Neoplastic
- Humans