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Article

[Alteration of the K-ras and p16/CDKN2 gene in endocrine pancreatic carcinomas].

Nihon rinsho. Japanese journal of clinical medicine - 1 May 2004

Shirahama Shuya, Matsuyoshi Junko, Yamamoto Shigeki, Tsukada Yutaka

Abstract excerpt

There are many observation of genetic alterations in pancreatic carcinoma. Mutation of codon 12 of K-ras gene relating to cell growth signaling was reported as high as 90%, and p16/CDKN2 gene regulating cell cycle are frequently altered by point mutation, homozygous deletion, or methylation in pancreatic carcinoma. Mutations of K-ras and p16 gene in endocrine pancreatic carcinomas were reported 15-58% in...

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PMID: 15148814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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