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Article

Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.

Biochemistry - 28 Jun 2011

Li Junan, Poi Ming Jye, Tsai Ming-Daw

Abstract excerpt

P16(INK4A) (also known as P16 and MTS1), a protein consisting exclusively of four ankyrin repeats, is recognized as a tumor suppressor mainly because of the prevalence of genetic inactivation of the p16(INK4A) (or CDKN2A) gene in virtually all types of human cancers. However, it has also been shown that an elevated level of expression (upregulation) of P16 is involved in cellular senescence, aging, and cancer...

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Identifiers

PMID: 21619050
DOI: 10.1021/bi200642e
PMCID: PMC3127263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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