Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer.

Digestive diseases and sciences - 1 Sept 2008

Ishida Masaharu, Sunamura Makoto, Furukawa Toru, Lefter Liviu P, Morita Rina, Akada Masanori, Egawa Shinichi, Unno Michiaki, Horii Akira

Abstract excerpt

Frequent loss of heterozygosity on the long arm of chromosome 18 is observed in pancreatic cancer. Previous studies suggested the existence of one or more tumor-suppressor genes other than SMAD4 on chromosome 18. To identify the candidate tumor-suppressor gene(s), we compared gene expression by cDNA microarray analyses using a pancreatic cancer cell line Panc-1 and its hybrid cell lines showing suppressed cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 18
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Microarray Analysis

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins c-bcl-2

Share to RNA Interference

Share to Transplantation, Heterologous

Source

Identifiers

PMID: 18231856
DOI: 10.1007/s10620-007-0154-1

Genes

PMAIP1
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer.PMID 18231856Read ↗

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.Semantic proximity Read ↗

Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis.Semantic proximity Read ↗

Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Identification of a Putative Tumor Suppressor Gene <i>Rap1GAP</i> in Pancreatic CancerSemantic proximity Read ↗

Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses.Semantic proximity Read ↗

<i>Intersex-like</i> ( <i>IXL</i> ) Is a Cell Survival Regulator in Pancreatic Cancer with 19q13 AmplificationSemantic proximity Read ↗

Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines.Semantic proximity Read ↗

Homozygous deletion map at 18q21.1 in pancreatic cancer.Semantic proximity Read ↗

Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.Semantic proximity Read ↗

Collateral Lethality in Pancreatic Cancer.Semantic proximity Read ↗

p8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth.Semantic proximity Read ↗

Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.