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Article

Low Frequency of p16INK4a Alterations in Insulinomas

1 Jan 2000

Abstract excerpt

BACKGROUND/AIMS: The molecular mechanisms contributing to the tumorigenesis of insulinomas are poorly understood. Disruption of the cell cycle due to inactivation of the p16(INK4a) tumor-suppressor gene was identified in a variety of human tumors, including gastrinomas and nonfunctioning endocrine pancreatic carcinomas. In this study the role of p16(INK4a) in the tumorigenesis of insulinomas was evaluated....

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Identifiers

PMID: 11025365
DOI: 10.1159/000007810

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