Article
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.
Nature structural & molecular biology - 1 Jun 2010
Bouwman Peter, Aly Amal, Escandell Jose M, Pieterse Mark, Bartkova Jirina, van der Gulden Hanneke, Hiddingh Sanne, Thanasoula Maria, Kulkarni Atul, Yang Qifeng, Haffty Bruce G, Tommiska Johanna, Blomqvist Carl, Drapkin Ronny, Adams David J, Nevanlinna Heli, Bartek Jiri, Tarsounas Madalena, Ganesan Shridar, Jonkers Jos
Abstract excerpt
Germ-line mutations in breast cancer 1, early onset (BRCA1) result in predisposition to breast and ovarian cancer. BRCA1-mutated tumors show genomic instability, mainly as a consequence of impaired recombinatorial DNA repair. Here we identify p53-binding protein 1 (53BP1) as an essential factor for sustaining the growth arrest induced by Brca1 deletion. Depletion of 53BP1 abrogates the ATM-dependent checkpoint...
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