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Article

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer.

Nature cell biology - 1 Dec 2002

DiTullio Richard A, Mochan Tamara A, Venere Monica, Bartkova Jirina, Sehested Maxwell, Bartek Jiri, Halazonetis Thanos D

Abstract excerpt

53BP1 is a conserved nuclear protein that is implicated in the DNA damage response. After irradiation, 53BP1 localizes rapidly to nuclear foci, which represent sites of DNA double strand breaks, but its precise function is unclear. Using small interference RNA (siRNA), we demonstrate that 53BP1 f...

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Source

Identifiers

PMID: 12447382
DOI: 10.1038/ncb892

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12447382-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer.PMID 12447382Read ↗

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53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.Semantic proximity Read ↗

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