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Article

Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

1 Aug 2007

Abstract excerpt

Human (h)PTIP plays important but poorly understood roles in cellular responses to DNA damage. hPTIP interacts with 53BP1 tumour suppressor but only when 53BP1 is phosphorylated by ATM after DNA damage although the mechanism(s) and significance of the interaction of these two proteins are unclear. Here, we pinpoint a single ATM-phosphorylated residue in 53BP1--Ser25--that is required for binding of 53BP1 to...

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PMID: 17690115
DOI: 10.1093/nar/gkm493

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Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damagePMID 17690115Read ↗

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