Article
Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers.
PloS one - 9 Nov 2009
Li Liang, Fridley Brooke L, Kalari Krishna, Jenkins Gregory, Batzler Anthony, Weinshilboum Richard M, Wang Liewei
Abstract excerpt
Cancer patients show large individual variation in their response to chemotherapeutic agents. Gemcitabine (dFdC) and AraC, two cytidine analogues, have shown significant activity against a variety of tumors. We previously used expression data from a lymphoblastoid cell line-based model system to identify genes that might be important for the two drug cytotoxicity. In the present study, we used that same model...
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