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Article

Genetic variants contributing to daunorubicin-induced cytotoxicity.

Cancer research - 1 May 2008

Huang R Stephanie, Duan Shiwei, Kistner Emily O, Bleibel Wasim K, Delaney Shannon M, Fackenthal Donna L, Das Soma, Dolan M Eileen

Abstract excerpt

Identifying heritable genetic variants responsible for chemotherapeutic toxicities has been challenging due in part to its multigenic nature. To date, there is a paucity of data on genetic variants associated with patients experiencing severe myelosuppression or cardiac toxicity following treatment with daunorubicin. We present a genome-wide model using International HapMap cell lines that integrate genotype and...

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Share to Antibiotics, Antineoplastic
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP1B1

Share to Cytochrome P-450 Enzyme System

Share to Daunorubicin

Share to Drug Resistance, Neoplasm

Share to Genetic Linkage

Share to Inhibitory Concentration 50

Source

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Identifiers

PMID: 18451141
DOI: 10.1158/0008-5472.CAN-07-6381
PMCID: PMC2714371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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