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Article

A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2007

Huang R Stephanie, Duan Shiwei, Bleibel Wasim K, Kistner Emily O, Zhang Wei, Clark Tyson A, Chen Tina X, Schweitzer Anthony C, Blume John E, Cox Nancy J, Dolan M Eileen

Abstract excerpt

Large interindividual variance has been observed in sensitivity to drugs. To comprehensively decipher the genetic contribution to these variations in drug susceptibility, we present a genome-wide model using human lymphoblastoid cell lines from the International HapMap consortium, of which extensive genotypic information is available, to identify genetic variants that contribute to chemotherapeutic agent-induced...

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Antineoplastic Agents, Phytogenic
Black People
Etoposide
Inhibitory Concentration 50

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacogenetics

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PMID: 17537913
DOI: 10.1073/pnas.0703736104
PMCID: PMC1887589

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AGPAT2

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