Article
Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans.
PloS one - 1 Jan 2011
Wheeler Heather E, Gorsic Lidija K, Welsh Marleen, Stark Amy L, Gamazon Eric R, Cox Nancy J, Dolan M Eileen
Abstract excerpt
Chemotherapeutic agents are used in the treatment of many cancers, yet variable resistance and toxicities among individuals limit successful outcomes. Several studies have indicated outcome differences associated with ancestry among patients with various cancer types. Using both traditional SNP-based and newly developed gene-based genome-wide approaches, we investigated the genetics of chemotherapeutic...
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