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Article

Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity.

Blood - 5 Mar 2009

Hartford Christine M, Duan Shiwei, Delaney Shannon M, Mi Shuangli, Kistner Emily O, Lamba Jatinder K, Huang R Stephanie, Dolan M Eileen

Abstract excerpt

Cytarabine arabinoside (ara-C) is an antimetabolite used to treat hematologic malignancies. Resistance is a common reason for treatment failure with adverse side effects contributing to morbidity and mortality. Identification of genetic factors important in susceptibility to ara-C cytotoxicity may allow for individualization of treatment. We used an unbiased whole-genome approach using lymphoblastoid cell lines...

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Identifiers

PMID: 19109566
DOI: 10.1182/blood-2008-05-154302
PMCID: PMC2652364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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