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Article

Association of thymidylate synthase variants with 5-fluorouracil cytotoxicity.

Pharmacogenetics and genomics - 1 May 2009

Peters Eric J, Kraja Aldi T, Lin Shiow J, Yen-Revollo Jane L, Marsh Sharon, Province Michael A, McLeod Howard L

Abstract excerpt

Identifying relevant cytotoxicity genes using an ex-vivo lymphoblastoid cell line (LCLs) model has distinct advantages for pharmacogenomic discovery studies of cancer chemotherapy, including standardized treatment conditions, availability of large numbers of samples, and publicly available genotypic data. However, there is little proof of principal data to confirm the promise of this approach. One of the known...

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Share to Antimetabolites, Antineoplastic
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug-Related Side Effects and Adverse Reactions

Share to Drug Screening Assays, Antitumor

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 19339911
DOI: 10.1097/FPC.0b013e328329fdec

Genes

TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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