Article
Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients.
Blood - 23 May 2013
Gamazon Eric R, Lamba Jatinder K, Pounds Stanley, Stark Amy L, Wheeler Heather E, Cao Xueyuan, Im Hae K, Mitra Amit K, Rubnitz Jeffrey E, Ribeiro Raul C, Raimondi Susana, Campana Dario, Crews Kristine R, Wong Shan S, Welsh Marleen, Hulur Imge, Gorsic Lidija, Hartford Christine M, Zhang Wei, Cox Nancy J, Dolan M Eileen
Abstract excerpt
A whole-genome approach was used to investigate the genetic determinants of cytarabine-induced cytotoxicity. We performed a meta-analysis of genome-wide association studies involving 523 lymphoblastoid cell lines (LCLs) from individuals of European, African, Asian, and African American ancestry. Several of the highest-ranked single-nucleotide polymorphisms (SNPs) were within the mutated in colorectal cancers...
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