Article
Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain.
Oncogene - 16 May 1996
Jacobs H, Ossendorp F, de Vries E, Ungewiss K, von Boehmer H, Borst J, Berns A
Abstract excerpt
In transgenic mice expressing a mutated T cell receptor (TCR) beta chain lacking the variable domain (DeltaV-TCRbeta) T cell differentiation is arrested at the CD4+ CD8+ thymocyte stage. Here, we report that these transgenic animals develop CD4+, CD8+, IL-2 receptor alpha-positive T cell lymphoma...
Topics
- Amino Acid Sequence
- Animals
- CD3 Complex
- CD4 Antigens
- CD8 Antigens
- Cell Differentiation
- DNA Nucleotidyltransferases
- Female
- Immunoglobulin Variable Region
- Integrases
- Lymphoma, T-Cell
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mice, Transgenic
- Molecular Sequence Data
- Mutation