Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue.

Developmental cell - 10 Jun 2013

Bardet Pierre-Luc, Guirao Boris, Paoletti Camille, Serman Fanny, Léopold Valentine, Bosveld Floris, Goya Yûki, Mirouse Vincent, Graner François, Bellaïche Yohanns

Abstract excerpt

Planar cell rearrangements control epithelial tissue morphogenesis and cellular pattern formation. They lead to the formation of new junctions whose length and stability determine the cellular pattern of tissues. Here, we show that during Drosophila wing development the loss of the tumor suppressor PTEN disrupts cell rearrangements by preventing the lengthening of newly formed junctions that become unstable and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial Cells
Share to Epithelium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to Intercellular Junctions

Share to Morphogenesis

Share to Myosin Type II

Share to PTEN Phosphohydrolase

Share to Wings, Animal

Source

Identifiers

PMID: 23707736
DOI: 10.1016/j.devcel.2013.04.020

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue.PMID 23707736Read ↗

Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity.Semantic proximity Read ↗

Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation.Semantic proximity Read ↗

p120-catenin controls contractility along the vertical axis of epithelial lateral membranes.Semantic proximity Read ↗

Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway.Semantic proximity Read ↗

Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers.Semantic proximity Read ↗

Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity.Semantic proximity Read ↗

Sticky business: orchestrating cellular signals at adherens junctions.Semantic proximity Read ↗

p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis.Semantic proximity Read ↗

Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary GlandSemantic proximity Read ↗

PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium.Semantic proximity Read ↗

ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.Semantic proximity Read ↗

Disease-related non-muscle myosin IIA D1424N rod domain mutation, but not R702C motor domain mutation, disrupts mouse ocular lens fiber cell alignment and hexagonal packing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.