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Article

Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Tao Hirotaka, Suzuki Makoto, Kiyonari Hiroshi, Abe Takaya, Sasaoka Toshikuni, Ueno Naoto

Abstract excerpt

Planar cell polarity (PCP) genes are essential for establishing planar cell polarity in both invertebrate and vertebrate tissues and are known to regulate cellular morphogenesis and cell movements during development. We focused on Prickle, one of the core components of the PCP pathway, and deleted one of two mouse prickle homologous genes, mpk1. We found that the deletion of mpk1 gene resulted in early embryonic...

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Identifiers

PMID: 19706528
DOI: 10.1073/pnas.0901332106
PMCID: PMC2732806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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