Disease-related non-muscle myosin IIA D1424N rod domain mutation, but not R702C motor domain mutation, disrupts mouse ocular lens fiber cell alignment and hexagonal packing.

doi:10.1002/cm.21853

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Article

Disease-related non-muscle myosin IIA D1424N rod domain mutation, but not R702C motor domain mutation, disrupts mouse ocular lens fiber cell alignment and hexagonal packing.

Cytoskeleton (Hoboken, N.J.) - 1 Dec 2024

Islam Sadia T, Cheheltani Sepideh, Cheng Catherine, Fowler Velia M

Abstract excerpt

The mouse ocular lens is an excellent vertebrate model system for studying hexagonal cell packing and shape changes during tissue morphogenesis and differentiation. The lens is composed of two types of cells, epithelial and fiber cells. During the initiation of fiber cell differentiation, lens epithelial cells transform from randomly packed cells to hexagonally shaped and packed cells to form meridional row...

Topics

Animals
Lens, Crystalline
Mice
Nonmuscle Myosin Type IIA
Mutation
Protein Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 38516850
DOI: 10.1002/cm.21853
PMCID: PMC11416570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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