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Article

Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity.

Nature cell biology - 1 May 2015

Luxenburg Chen, Heller Evan, Pasolli H Amalia, Chai Sophia, Nikolova Maria, Stokes Nicole, Fuchs Elaine

Abstract excerpt

During mouse development, core planar cell polarity (PCP) proteins become polarized in the epidermal plane to guide angling/morphogenesis of hair follicles. How PCP is established is poorly understood. Here, we identify a key role for Wdr1 (also known as Aip1), an F-actin-binding protein that enhances cofilin/destrin-mediated F-actin disassembly. We show that cofilin and destrin function redundantly in developing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25915128
DOI: 10.1038/ncb3146
PMCID: PMC4523270

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Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity.PMID 25915128Read ↗

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