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Article

PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium.

Current biology : CB - 5 Jun 2012

Lee Jianyi, Andreeva Anna, Sipe Conor W, Liu Lixia, Cheng Amy, Lu Xiaowei

Abstract excerpt

BACKGROUND: Planar cell polarity (PCP) signaling is a key regulator of epithelial morphogenesis, including neural tube closure and the orientation of inner ear sensory hair cells, and is mediated by a conserved noncanonical Wnt pathway. Ptk7 is a novel vertebrate-specific regulator of PCP, yet the mechanisms by which Ptk7 regulates mammalian epithelial PCP remain poorly understood. RESULTS: Here we show that, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Cells, Auditory, Inner

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Source

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Identifiers

PMID: 22560610
DOI: 10.1016/j.cub.2012.03.068
PMCID: PMC3407606

Genes

PTK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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