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Article

ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.

Nature communications - 17 Feb 2022

Royer Christophe, Sandham Elizabeth, Slee Elizabeth, Schneider Falk, Lagerholm Christoffer B, Godwin Jonathan, Veits Nisha, Hathrell Holly, Zhou Felix, Leonavicius Karolis, Garratt Jemma, Narendra Tanaya, Vincent Anna, Jones Celine, Child Tim, Coward Kevin, Graham Chris, Fritzsche Marco, Lu Xin, Srinivas Shankar

Abstract excerpt

During development, pseudostratified epithelia undergo large scale morphogenetic events associated with increased mechanical stress. Using a variety of genetic and imaging approaches, we uncover that in the mouse E6.5 epiblast, where apical tension is highest, ASPP2 safeguards tissue integrity. It achieves this by preventing the most apical daughter cells from delaminating apically following division events. In...

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Identifiers

PMID: 35177595
DOI: 10.1038/s41467-022-28590-4
PMCID: PMC8854694

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