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Article

Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.

RNA (New York, N.Y.) - 1 May 2016

Mayerle Megan, Guthrie Christine

Abstract excerpt

Pre-mRNA splicing must occur with high fidelity and efficiency for proper gene expression. The spliceosome uses DExD/H box helicases to promote on-pathway interactions while simultaneously minimizing errors. Prp8 and Snu114, an EF2-like GTPase, regulate the activity of the Brr2 helicase, promoting RNA unwinding by Brr2 at appropriate points in the splicing cycle and repressing it at others. Mutations linked to...

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Identifiers

PMID: 26968627
DOI: 10.1261/rna.055459.115
PMCID: PMC4836653

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Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.PMID 26968627Read ↗

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