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Article

Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa.

Molecular cell - 23 Feb 2007

Pena Vladimir, Liu Sunbin, Bujnicki Janusz M, Lührmann Reinhard, Wahl Markus C

Abstract excerpt

Protein Prp8 interacts with several other spliceosomal proteins, snRNAs, and the pre-mRNA and thereby organizes the active site(s) of the spliceosome. The DEAD-box protein Brr2 and the GTPase Snu114 bind to the Prp8 C terminus, a region where mutations in human Prp8 are linked to the RP13 form of Retinitis pigmentosa. We show crystallographically that the C-terminal domain of yeast Prp8p exhibits a Jab1/MPN-like...

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Identifiers

PMID: 17317632
DOI: 10.1016/j.molcel.2007.01.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa.PMID 17317632Read ↗

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