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Article

The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA.

Nucleic acids research - 1 Aug 2013

Law Michael J, Lee Diane S, Lee Charlene S, Anglim Paul P, Haworth Ian S, Laird-Offringa Ite A

Abstract excerpt

Previous kinetic investigations of the N-terminal RNA Recognition Motif (RRM) domain of spliceosomal A protein of the U1 small nuclear ribonucleoprotein particle (U1A) interacting with its RNA target U1 hairpin II (U1hpII) provided experimental evidence for a 'lure and lock' model of binding. The final step of locking has been proposed to involve conformational changes in an α-helix immediately C-terminal to the...

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Identifiers

PMID: 23703211
DOI: 10.1093/nar/gkt326
PMCID: PMC3737524

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Source receipt: pubmed, retrieved 7 Sept 2026.

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