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Article

The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA binding.

RNA (New York, N.Y.) - 1 May 2005

Kwan Sharon S, Brow David A

Abstract excerpt

Prp24 is an essential yeast U6 snRNP protein with four RNA recognition motifs (RRMs) that facilitates the association of U4 and U6 snRNPs during spliceosome assembly. Genetic interactions led to the proposal that RRMs 2 and 3 of Prp24 bind U6 RNA, while RRMs 1 and 4 bind U4 RNA. However, the function of each RRM has yet to be established through biochemical means. We compared the binding of recombinant...

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Identifiers

PMID: 15811912
DOI: 10.1261/rna.2010905
PMCID: PMC1370765

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA binding.PMID 15811912Read ↗

Structure and interactions of the first three RNA recognition motifs of splicing factor prp24.Semantic proximity Read ↗

A conserved Lsm-interaction motif in Prp24 required for efficient U4/U6 di-snRNP formation.Semantic proximity Read ↗

Specificity of Prp24 binding to RNA: a role for Prp24 in the dynamic interaction of U4 and U6 snRNAs.Semantic proximity Read ↗

Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.Semantic proximity Read ↗

The 5' and 3' domains of yeast U6 snRNA: Lsm proteins facilitate binding of Prp24 protein to the U6 telestem region.Semantic proximity Read ↗

Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs.Semantic proximity Read ↗

Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8.Semantic proximity Read ↗

Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.Semantic proximity Read ↗

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.Semantic proximity Read ↗

An extragenic suppressor of prp24-1 defines genetic interaction between PRP24 and PRP21 gene products of Saccharomyces cerevisiae.Semantic proximity Read ↗

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome.Semantic proximity Read ↗

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