Article
Characterization of the dynamics of an essential helix in the U1A protein by time-resolved fluorescence measurements.
The journal of physical chemistry. B - 15 May 2008
Anunciado Divina, Agumeh Michael, Kormos Bethany L, Beveridge David L, Knee Joseph L, Baranger Anne M
Abstract excerpt
The RNA recognition motif (RRM), one of the most common RNA-binding domains, recognizes single-stranded RNA. A C-terminal helix that undergoes conformational changes upon binding is often an important contributor to RNA recognition. The N-terminal RRM of the U1A protein contains a C-terminal helix (helix C) that interacts with the RNA-binding surface of a beta-sheet in the free protein (closed conformation), but...
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