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Article

Native conformational dynamics of the spliceosomal U1A protein.

The journal of physical chemistry. B - 5 Mar 2015

Guzman Irisbel, Ghaemi Zhaleh, Baranger Anne, Luthey-Schulten Zaida, Gruebele Martin

Abstract excerpt

The complex of spliceosomal U1A protein and its cognate SL2 RNA is a prototype system for protein-RNA binding studies. A major question is whether U1A protein alone is capable of undergoing conformational dynamics similar to structural rearrangements upon RNA binding. Using a fast temperature jump and tryptophan fluorescence detection, we uncover a ∼20 μs conformational transition for the Lys22Gln/Phe56Trp-only...

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Identifiers

PMID: 25659967
DOI: 10.1021/jp511760m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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