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Profiling of UV-induced ATM/ATR signaling pathways

6 Dec 2007

Abstract excerpt

To ensure survival in the face of genomic insult, cells have evolved complex mechanisms to respond to DNA damage, termed the DNA damage checkpoint. The serine/threonine kinases ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR) activate checkpoint signaling by phosphorylating substrate proteins at SQ/TQ motifs. Although some ATM/ATR substrates (Chk1, p53) have been identified, the lack of a more...

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PMID: 18077418
DOI: 10.1073/pnas.0707579104

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